スイス・バーゼルに本社を置く医学ジャーナル出版社より招聘状をいただき、MDPIが刊行する Journal of Clinical Medicine (JCM) のゲストエディターに就任しました。私が編集長として携わるのは「小児急性脳症」の臨時特集号で、2023年2月25日まで一年間のオンラインIssueになります。JCMは当該分野の学術ジャーナルとしては最高位のQ1レベルにランクする総合医学雑誌で、 2018年にはImpact Factor 5.583と高く評価されています。

https://www.mdpi.com/journal/jcm/special_issues/Pediatric_Encephalopathy

https://twitter.com/JCM_MDPI/status/1485901291658235904

Special Issue Editor, Dr. George Imataka MD, PhD, B.Phil, LL.B, PGDBA

Dear Colleagues,

In the brain dysfunction associated with pediatric acute encephalopathy, there is a spectrum of clinical symptoms, including impaired consciousness, motor and sensory deficits, and status convulsives. What mechanisms are occurring in the brain of someone with pediatric acute encephalopathy? In the 1960s, pediatric acute encephalopathy was pathologically proven to be a cellular edema of the brain. Since the 1970s, research on encephalopathy caused by various inborn errors of metabolism has progressed. Since the 1980s, evidence from CT brain imaging has been accumulated. The diagnosis of acute encephalopathy due to various causes such as infections, epilepsy, cerebrovascular disorders, electrolyte abnormalities, and drugs was also advanced, and Reye syndrome and Hypoxic–ischemic encephalopathy in neonates and children was proposed. In the 1990s, the diagnosis of acute disseminated encephalomyelitis and acute necrotizing encephalopathy was advanced. Since around 2000, the classification of encephalopathy by neuroradiological diagnosis has been established, including biphasic encephalopathy that develops after status epilepticus/convulsives and mild encephalopathy with abnormal signals in the corpus callosum on MRI scans. Nowadays, we have established the classification of encephalopathy into categories such as encephalopathy caused by cytokine storms, status epilepticus due to excitotoxicity, and encephalopathy caused by metabolic crises.  Encephalopathy caused by genetic abnormalities such as CPT2 and SCN1A is also being elucidated. The treatment methods have also advanced, including steroid pulse therapy, immunotherapy, brain hypothermia, and temperature control therapy. In this Special Issue, we would like to share a comprehensive review of pediatric acute encephalopathy, highlighting the latest clinical data and basic research data and covering future developments in pediatric acute encephalopathy.

Therefore, researchers are encouraged to submit an original article or review to this Special Issue (case reports and short reviews are not accepted).

Guest Editor, 

Dr. George Imataka

Keywords

• acute encephalopathy / acute encephalitis
• acute disseminated encephalitis (ADEM)
• acute encephalopathy with febrile convulsive status epilepticus (AEFCSE)
• acute encephalopathy with buphasic seizures and late reduced diffusion (AESD)
• acute encephalitis with refractory, repetitive partial seizures (AERRPS)
• acute infantile encephalopathy predominantly affecting the frontal lobes (AIEF)
• acute necrotizing encephalipathy (ANE)
• febrile infection-related epilepsy syndrome (FIRES)
• hemorrhagic shock and encephalopathy syndrome (HSES)
• mild encephalitis / encephalopathy with a reversible splenial lesion (MERS)
• posterior reversible encephalopathy syndrome (PRES)

Published Papers

This special issue is now open for submission.